S464 Lihncs - Lugol's Iodine in Head and Neck Cancer Surgery: a Multicentre, Randomised Controlled Trial Assessing the Effectiveness of Lugol’s Iodine to Assist Excision of Moderate Dysplasia, Severe Dysplasia and Carcinoma in Situ at Mucosal Resection Margins
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چکیده
MULTICENTRE, RANDOMISED CONTROLLED TRIAL ASSESSING THE EFFECTIVENESS OF LUGOL’S IODINE TO ASSIST EXCISION OF MODERATE DYSPLASIA, SEVERE DYSPLASIA AND CARCINOMA IN SITU AT MUCOSAL RESECTION MARGINS Jim A McCaul, Professor, James A Cymerman, Mr, Stuart W Hislop, Mr, Chris McConkey, Mr, Jeremy D McMahon, Mr, Hisham Mehanna, Professor, Richard J Shaw, Mr, David N Sutton, Mr, Davie Gouldesbrough, Dr, Janet Dunn, Professor; Maxillofacial/ Head and Neck Research, Bradford Institute for Health Research, University of Warwick Clinical Trials Unit
منابع مشابه
LIHNCS - Lugol’s iodine in head and neck cancer surgery: a multicentre, randomised controlled trial assessing the effectiveness of Lugol’s iodine to assist excision of moderate dysplasia, severe dysplasia and carcinoma in situ at mucosal resection margins of oral and oropharyngeal squamous cell carcinoma: study protocol for a randomised controlled trial
BACKGROUND Oral cavity and oropharynx cancer are increasing in incidence worldwide but survival outcomes have not significantly improved over the last three decades. The presence of dysplasia or carcinoma in situ at surgical margins following resection of squamous carcinoma of the mucosal surfaces of the head and neck has been shown to be associated with a higher incidence of local recurrence a...
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Oral squamous cell carcinoma (OSCC) is often surrounded by epithelial dysplasia; leaving it unresected can result in local recurrence. Staining with Lugol's iodine solution detects epithelial dysplasia in oral mucosa, but whether it decreases local recurrence after OSCC surgery is unknown. This study investigated local recurrence rates in patients with early tongue cancer who underwent surgery ...
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